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Zingiberene, a sesquiterpene compound and the primary constituent of ginger essential oil, exhibits anti-cancer, antioxidant, antibacterial, anti-inflammatory and anti-angiogenic activities

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that the activation of mGluR1 by glutamate in SK2 and SK5 human melanoma cell lines resulted in an increase in cell viability at the concentration of 4.3 mM and 3.4 mM respectively for SK2 and SK5 independent of the canonical PLC and PI signaling pathways