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Heres what the research shows it can do: Stimulate new blood vessel growth to injured areas (angiogenesis) Accelerate healing in tendons, ligaments, and connective tissue Reduce inflammation without suppressing immune function Protect nerve cells and support nerve regeneration Promote cartilage repair and joint tissue recovery The anti-inflammatory effect without immune suppression is particularly notable

In general, topical medications (such as creams or ointments) are going to have much less systemic absorption, and typically have little impact on male fertility potential

Hoover Institution: Library & Archives

This is because implementation of such effects may involve not only the levels of REST expression but also post-translational modifications of REST as well as various cofactors necessary for this proteins function 71