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What Is Testosterone Replacement Therapy (TRT)

In the presence of traces of redox-active transition metals, hydrogen peroxide can generate hydroxyl radicals (via the Fenton reaction)

Xin Yao, Jiaqi Huang, Haihong Zhong, Nan Shen, Raffaella Faggioni, Michael Fung, Yihong Yao, Targeting interleukin-6 in inflammatory autoimmune diseases and cancers, Pharmacology & Therapeutics, Volume 141, Issue 2, 2014, Pages 125-139, ISSN 0163-7258, 3

For example, copper ions can lead to GSH depletion through two mechanisms: the direct downregulation via the redox reaction between Cu 2+ and intracellular GSH, and the activation of a Fenton-like reaction by generating Cu + to amplify oxidative stress ( in situ GSH in tumor triggered mCMSNs biodegradation and reduced Cu 2+ into Cu + for enhanced hydroxyl radical production, leading to a powerful inhibition effect on tumors (Liu et al., 2019)