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However, when the cells were exposed to the stable cGMP analog 8-Bromo-cGMP (8Br-cGMP, 100 M), sGC activator BAY 58-2667 (Bay58, 1 M), or sGC stimulator BAY 41-2272 (Bay41, 1 M), we observed a reduction in TGF-1mediated expression of osteopontin (encoded by Spp1 ) (Figure 7A)