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doi: 10.1056/NEJMoa073493 16 International Multiple Sclerosis GeneticsCWellcome Trust Case ControlCSawcerSHellenthalGPirinenMSpencerCCet al

Cellular Factors and Signaling The reactivation of KSHV can be initiated artificially by treating latently infected cells with certain chemicals such as 12-O-Tetradecanoyl-phorbol-13-acetate (TPA) and sodium butyrate (Miller et al., 1997)

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Several studies have shown that TGF-1 upregulates glutaminase 1 (GLS1), enhancing the conversion of glutamine to glutamate, a critical step for collagen biosynthesis [97,98,99]