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The nano-emulsion acted simultaneously by decreasing the mitochondrial membrane potential, raising pro-apoptotic Bax levels, and diminishing anti-apoptotic Bcl-2 protein in the drug-resistant cell line [261]

Furthermore, the HUVEC cells were incubated with different concentrations of uricase (0, 0.5, 1, 2.5, 5 U/mL), PDA@Pt (0, 25, 50, 75, 100 g/mL), and UA (1 mM) for 24 h

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