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Description

The pairwise sequence alignments show the CSD site has been undergoing rapid evolution since its introduction in both clades (Figure S2)

Alkynylated probes derived from senolytic chloroacetamides A detailed description of the synthesis of alkynylated probes derived from senolytic chloroacetamides and the NMR spectra of the synthesized probes is provided in Supplementary Note 1

Although, cells physiologically produce a certain amount of ROS (e.g.: respiratory chain in mitochondria), excessive production has the potential to significantly damage cell homeostasis, mainly through oxidative modifications of DNA/RNA and proteins