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Research using Morris water maze (spatial memory), passive and active avoidance (fear-motivated learning), novel object recognition, and operant conditioning tasks shows that Semax improves acquisition, consolidation, and retrieval of memory in both normal animals and those with experimentally induced cognitive impairment

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This is accompanied by a reduction in both granulocytic and monocytic MDSCs, highlighting the potential of 2-AR inhibition to impair MDSC function and alleviate immunosuppression in the TME

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