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Data availability Nucleotide sequences generated in this study have been submitted to GenBank (Accession numbers PV533895-PV533904, PV764712-PV764746)

Its application in COPD drug screening can facilitate the discovery of compounds that preserve alveolar integrity, reduce inflammation, and mitigate oxidative damage, ultimately bridging the gap between regulatory and preclinical research applications

After treatment, no significant differences in the organ index of typical major organs, fetuses, and placentas were found between the control and nanotherapy groups (Supplementary Fig