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Advisor: Jennifer Puck, MD., Professor of Immunology and Pediatrics, The University of California San Francisco Staff Research Associate I, University of California Riverside 2012-2013 Project: Classify the effects of N-terminal truncation mutations of the IFITM family of innate immune proteins to explore the clinical significance of the rs-12252-C polymorphisms during influenza A pandemics Project goal: Understand how genetic variants in innate immune proteins (the single nucleotide polymorphism rs-12252-C) affect the susceptibility of different populations to Influenza A infection

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Mechanistic studies indicate that the NHL domain of TRIM3 interacts with the Xc system, leading to K37 ubiquitination of SCL7A11