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Itaconate promotes tumor growth via oxidative phosphorylation-driven ROS generation in peritoneal tissue-resident macrophages and concomitant ROS-mediated mitogen-activated protein kinases (MAPKs) activation in tumor cells (79)

However, the pentose phosphate pathway can also return metabolites to glycolysis, because fructose-6-phosphate and glyceraldehyde-3-phosphate are also formed in the non-oxidative phase

The IV format typically allows for a large spike in blood levels which helps drive key mood regulating substances into the brain

By using ferroptosis inducers, it is possible to enhance iron accumulation and ROS levels in GC cells, thereby triggering ferroptosis and suppressing cell proliferation (71)