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Other symptoms of vitamin B12 deficiency include: Rapid breathing or shortness of breath Headaches Indigestion Diarrhea Loss of appetite Problems with vision Feeling weak or tired Psychological problems, which can range from mild depression or anxiety to confusion and dementia Blood tests are the most common way to diagnose a vitamin B-12 deficiency

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MTHFR Gene Mutation Individuals with gene mutations such as MTHFR or MTRR have trouble with the process of methylating B12 into its usable form