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The active site cysteine of the proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase is essential in oxidative stress-induced aggregation and cell death

Although the effects of vitamin E in neurodegenerative diseases, including PD, are not completely understood, there are various potential mechanisms underlying the risk of PD, such as the neuroprotective effect of vitamin E against oxidative stress damage and the inhibition of the expression of many genes involved in neurodegeneration development