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it was observed that, following the entry of APAP in hepatocytes, the greatest proportion of APAP (90%) is converted to innocuous molecules, and only a small fraction of APAP (510%) yields the toxic electrophile N-acetyl-para-benzoquinoimine (NAPQI), due to the activity of cytochrome P450 isoforms, mainly CYP 2E1, CYP 1A2, CYP 3A2 (234)

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