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In addition, we discuss the newly elucidated strategies by which Mtb manipulates the host molecular regulatory machinery of innate immunity, including the intranuclear regulatory machinery, the ubiquitin system, and cellular intrinsic immune components

TMEM164 has also been suggested to induce autophagy, resulting in ferritin, GPX4, and lipid droplet degradation 136

When combined with appropriate loading, nutrition, and recovery habits, this systems-based approach can help patients move beyond flare cycles and toward durable resilience

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