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However, there have been indications that regular doses of 1 g over extended periods, such as months or years, may reduce bactericidal activity in leukocytes and increase the risk of stone formation caused by temporary urate excretion elevation

RT-qPCR analysis revealed that key metabolic genes, including gnd , PxpA , HBL79_RS05810 , HBL79_RS03605 , and EIIB were significantly downregulated, consistent with our transcriptomic results (Figures 4AF)