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It was also observed that the expression of truncated sortilin and the small interfering RNA (siRNA)-mediated knockdown of sortilin in primary neurons resulted in the missorting of BDNF to the constitutive pathway, further supporting the finding that sortilin regulates the sorting of BDNF to the RSP [9]

In parallel with these resistance trends, the global population of immunocompromised individuals, including patients with malignancies, transplant recipients, individuals with HIV infection, and those receiving immunosuppressive therapies, is steadily increasing, further amplifying the clinical burden and therapeutic complexity of resistant candidiasis (Sahu et al., 2026a