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Increasing evidence suggests that this axis exerts a profound influence on key neurobiological processes, including neuroinflammation, BBB permeability, neurotransmission, and synaptic plasticity, all of which are directly relevant to neurodegeneration and neuroprotection [615, 616]

It is structurally similar to glutamate, but the carboxylic acid group of the side chain is replaced by an amide

Indeed, plasma reactive oxygen species (ROS), C-reactive protein (CRP), and interleukin-6 (IL-6) levels were increased in a dose-dependent manner in atomic bomb survivors 6

In conclusion, the discovery of copper-mediated apoptosis has further refined the specific anti-cancer mechanism of elesclomol