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For instance, a study has reported that melatonin could enhance the developmental potential of porcine oocyte-granulosa cell complexes derived from preantral follicles (90), while another research has showed that melatonin, combined with cyclic adenosine monophosphate (cAMP) modulators, could promote meiotic and developmental competence in porcine oocytes from early antral follicles during IVG and pre-maturation culture (91)

While this suggests that DNA methylation may contribute to MAPKAPK2 repression, definitive confirmationsuch as bisulfite sequencing or methylation-specific PCRremains to be performed

doi: 10.2337/db07-0381 5