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The sample size was determined based on a pre-experimental power analysis using data from a pilot study, which indicated that a minimum of n = 6 per group would provide 80% power to detect a 30% difference in primary outcomes at a significance level of = 0.05

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Other preliminary data suggest it may be useful as adjunctive palliative therapy in advanced biliary tract carcinoma (25) or protect against chemotherapy-induced liver toxicity (43) (44) (45)