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7.6 Integrative perspective and future outlook Taken together, both antioxidant-based and EV-based interventions face shared translational limitations rooted in model relevance, standardization, and clinical validation

While this is protective against age-related hyperfunction, it theoretically risks blunting the anabolic responses required for new synaptic formation, muscle hypertrophy, or exercise adaptation in subjects who are not already biologically aged

Safety Vital signs such as blood pressure (systolic and diastolic blood pressure), body temperature, pulse rate, and clinical laboratory tests (hematology, biochemical, and urine tests) were performed on the participants at each visit

Importantly, although A is generally localized toward the synapses, evidence from AD and Downs syndrome (DS) with early AD symptoms exhibit intraneuronal A 142 accumulation that precedes Tau pathology and extracellular A plaque formation (Takahashi et al., 2017