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Front Immunol (2020) 11:1021

783 Moreover, intracellularly accumulated F-1,6-BP can bind with HMGB1, decreasing the affinity of HMGB1 for DNA and DNA adducts and sensitizing cancer cells to DNA replication stress and damage induced by chemotherapeutic agents, thereby promoting cancer cell apoptosis

In humans, studies have linked reduced glutathione levels with many different health conditions. Studies have found the same for dogs and cats, too. For example, one study found that unwell dogs had lower levels of glutathione. If low glutathione levels are connected with poor health outcomes, you can start to see why maintaining glutathione levels is so important