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10.1016/j.pdpdt.2020.101677 125

Environmental factors inducing human cancers

Furthermore, GA inhibited the phosphorylation of PI3K, Akt and ERK, and regulated the expression of inflammatory proteins (reducing the activation of NF-B and Ras, and increasing the expression of iNOS and Kinase Suppressor of Ras 2), and increased the expression of Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN), thereby inhibiting TNF--induced cell proliferation (Chung et al., 2020)