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Excess iron accumulation during ferroptosis catalyses the Fenton reaction to produce lipid ROS, which oxidize low-density lipoprotein to form oxidized low-density lipoprotein, leading to lipid deposition, foam cell formation, and endothelial dysfunction

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While female patients demonstrated a higher burden of methylation dysregulation, they may possess certain biological mechanisms that mitigate more severe disease progression, potentially explaining the sex-specific differences in schizophrenia susceptibility (Zhou et al., 2023