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153 The extracellular matrix (ECM), a non-cellular component of the tumor microenvironment, has a physical structure and chemical composition often associated with tumor progression

Shock 46 , 5259 (2016)

This quinolinium cation structure enables selective recognition by the NNMT active site, where it acts as a competitive inhibitor with respect to nicotinamide substrate

We expect in the near future growing recognition of GSH involvement, by S -glutathionylation and/or by the thiols redox state shift, not only in the induction of ATG and/or apoptosis, but also in the modulation of activities of molecular/transcription factors such as NEF2L2, PGC1, and p53 that by inducing the antioxidant defense and assuring mitochondrial homeostasis could block both processes