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In GF mice, the absence of commensal bacteria specifically leads to underdeveloped mucosal lymphoid structures, including Peyers patches and germinal centers, as well as reduced secretory immune factors [35, 39]

First, aggregated peptide cannot bind to receptors properly, reducing or eliminating the therapeutic effect

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In the U.S., Agaricus bisporus is by far the most consumed species of mushroom, with around 97 % of all mushrooms produced belonging to that species, compared to other mushroom species (such as oyster mushrooms) which typically have a much higher ERGO content (Reference Beelman, Kalaras and Richie15)