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The challenges in targeting KRAS stem from its biological characteristics, such as a smooth surface lacking deep binding pockets and its high-affinity GTP-binding activity, which made the development of small-molecule inhibitors particularly difficult

In addition to direct effects on hepatic lipid synthesis, LXR repression exerts pleiotropic effects to reduce dyslipidemia

Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination