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FTO The tumorigenic function of FTO in malignancies r was initially established in research on melanoma, wherein particular FTO variants were linked to an elevated risk of developing melanoma

Spine 27, 13961401

Acknowledgements We sincerely thank all colleagues and collaborators whose insights and discussions contributed to the development of this manuscript

In Caucasian (white) skin, there is a specific group of polymorphic genes (with single nucleotide alterations) that encode for enzymes and transcription factors responsible for the early steps (including the first step, formation of L-DOPA from the amino acid tyrosine) of the melanin synthesis pathway