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doi: 10.3389/fimmu.2022.929520 17 GaoMYiJZhuJMinikesAMMonianPThompsonCBet al

This is the core mechanism

Numerous clinical treatment drugs for HCC, including bevacizumab, sorafenib, lenvatinib, regorafenib, and cisplatin, increase ROS levels, activating the intrinsic apoptotic pathway [243,244,245,246,247]