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Given that low lactate dehydrogenase levels represent a high mitochondrial metabolic state, this finding is consistent with the observation that cells with high levels of lipoylated TCA enzymes and a hyperactive mitochondrial respiratory rate are more sensitive to elesclomol

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Liu H-J, Tang Z-X, Han X-M, Yang Z-L, Zhang F-M, Yang H-L, Liu Y-J, Zeng Q-Y