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Distinguishing between them helps determine whether a medication adjustment is truly needed

One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition

The most common concentrations include 2.5mg/mL (typically in smaller 1 mL vials containing 2.5 mg total), 5mg/mL (in 1 mL vials containing 5 mg total or 2 mL vials containing 10 mg total), and occasionally higher concentrations for patients on maintenance doses

For pull-downs, we used two antibodies: against the full phospho-motif sequence of PKD LxRxx[S*/T*] and antibody against part of the PKD phospho-motif sequence Rxx[S*/T*]