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Storage protocol Step 1: Immediate refrigeration

These direct GHR-mediated metabolic effects are studied separately from the IGF-1-mediated anabolic axis using selective pathway inhibitors and GHR knockout models

Regulation of tight junctions and loss of barrier function in pathophysiology

Quercetin was demonstrated to inhibit ferroptosis and improve joint cartilage destruction and degradation, delaying OA progression, by activating the AMP-activated protein kinase (AMPK)/Nrf2/GPX4 signaling pathway (Dong et al., 2025)