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Elevated serotonin levels contribute to anxiety, panic attacks, and restlessness, exacerbating stress responses and impacting daily life

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The proposed expert opinion planned to provide a practical and implementable guidance document addressing DPN in terms of: a) definition, pathophysiology and risk factors, b) clinical manifestations and diagnosis (current challenges, a proposed screening and diagnostic algorithm), c) screening for early diagnosis and symptom progression, and d) management of disease in terms of the optimal diabetes treatment (intensive glycemic control, lifestyle modification and multifactorial risk intervention), the pathogenetically oriented pharmacotherapy (with special emphasis on alpha lipoic acid), and the symptomatic pain relief (in painful DPN)

Downregulation of human endogenous retrovirus type K (HERVK) viral env RNA in pancreatic cancer cells decreases cell proliferation and tumor growth