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noted V-B12 increased blood pressure and systemic vascular resistance in a hypovolemic hemorrhage swine model.68 Xu et al ., noted that vascular reactivity (i.e., vascular responsiveness to vasoconstrictors and vasodilators) increased in the early stage of trauma shock and decreased in late stages.69 Angiopoietin-1 and -2 may regulate this biphasic change

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