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For example, the chin area was always hyperactive and synkinetic, but showed a high degree of improvement even as the pharmacologic effect of BoNTA declined over time

Specifically, the global deletion of Zip14 in mice led to an increased ratio of fungi to bacteria in the fecal microbiome, at least partially driven by an increase in Saccharomyces cerevisiae, which has been linked to IBD (141, 142)