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Mart-Carvajal AJ, Gluud C, Arevalo-Rodriguez I, Mart-Amarista CE

Outcomes were assessed 30 days to 5 years after the initiation of pharmacotherapy

With the exception of acetylation, methylation and fatty acid conjugation, the strategy of phase II biotransformation is to convert a xenobiotic to a more hydrophilic form via the attachment of a chemical moiety which is ionizable at physiological pH