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The biological roles of Tau and its significance in AD Tau and neuronal microtubule and chromatin stability and stress granule formation Along with A, the tubulin associated unit (Tau) protein is considered a key player in AD pathogenesis as it forms the basis of intra-neuronal NFTs evident in AD, and displays a higher correlation with clinical AD symptom severity than does A (Congdon et al., 2023)

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(1995) Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation