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CRISPR-Cas12a (Clustered Regularly Interspaced Short Palindromic Repeats CRISPR associated protein 12a) biosensors achieved 96.5% sensitivity and 99% specificity for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) detection in saliva (n = 352 patients) relative to Reverse Transcription quantitative Polymerase Chain Reaction (RT-qPCR), showcasing the diagnostic potential of integrated biosensing approaches ( 2.2 Optical sensors Optical nano-biosensors detect analyte-receptor interactions through light absorption, fluorescence, surface plasmon resonance, and refractive index changes, offering real-time and highly sensitive detection for clinical and PoC applications (Mostufa et al., 2024)

While generation and application of antibodies are restricted to physiological conditions, aptamers can be generated under varying conditions during their in vitro selection

Consultado en octubre de 2023

Further, in certain embodiments, mobilization (for example, mobilization with GM-CSF) and conditioning regimens can be used to create a condition in a subject wherein repopulation, recirculation, regeneration, and/or expansion of particular cell types is favored, especially during a defined window of time following therapy