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The reason we advise 50 micrograms a day or 2,000 a week is because the less frequently you take vitamin B12, even at high doses, the percentage your body absorbs drops

Further, the conversion of both hydroxycobalamin and cyanocobalamin to the active Adenosyl and methyl cobalamins, also involve "Flavoproteins" (Obeid etal, 2015) and hence if a person takes or is injected with, high doses of hydroxycobalamin or cyanocobalamin and has functional B2 deficiency, the inactive hydroxycobalamin and cyanocobalamin will accumulate in serum, however the symptoms of vitamin B12 deficiency will not be resolved

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Medicines (Basel, Switzerland)