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The ROS content in the tissues was measured by fluorescence analysis (excitation, 482 nm

SAM S-adenosyl-L-methionine TAAs tumor-associated antigens MTD maximum tolerated dose Cmax peak concentration Tmax time to maximum plasma concentration T1/2 half-life AUC the area under the curve Vd volume of distribution NPEOC 2'-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl] MAGE melanoma-associated CT antigen DAPK1 death-associated protein kinase 1 TNBC triple-negative breast cancer EMT epithelial mesenchymal transition hTERT human telomerase reverse-transcriptase TIMP3 tissue inhibitor of matrix metalloproteinase 3 hENT1 human equilibrative nucleoside transporter 1 HDAC histone deacetyltransferase PDX patient-derived xenograft HKMT histone lysine methyltransferase HKDMT histone lysine demethylase References 1 AhmadI.RaoD

Extracellular Matrix and Connective Tissue Biology Healthy connective tissues rely on continuous remodeling of the extracellular matrix, coordinated cellular migration, and balanced communication between structural and immune cells

MMP-1 can degrade fibrillar collagen in its three-helical domain, which causes the molecules to be thermally unstable so that they break down to form gelatin, which can then be degraded by other members of the MMP family (126)