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doi: 10.1186/s12610-022-00157-9 85 FucikovaJKeppOKasikovaLPetroniGYamazakiTLiuPet al

Apoptosis can be initiated via two major pathways: the intrinsic (mitochondria-dependent) pathway, which is triggered by cellular stress and mitochondrial outer membrane permeabilization, and the extrinsic (death receptor-mediated) pathway, both of which converge on the activation of caspases to execute cell death [53]