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The classic approach to address this issue by a medicinal chemist is often to use a prodrug approach by connecting a brain targeting ligand to a drug molecule to form a prodrug and the drug is released after the prodrug enters the brain

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An antibody for integrin 3 was used as loading control, as we previously found that integrin 3 expression was relatively normal for GATA1-deficient platelets using flow cytometry.13 NBEAL2 blots were performed with a rabbit polyclonal (Figure 3A