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131 However, 24-day intravenous infusion of SAM did not affect the size of the formed tumors, which may be due to the compensatory induction of GNMT, and prevented SAM accumulation

A., Kumar, N

(12) Stefan M, et al

Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning