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Opiorphin ist ein Pentapeptid (Gln-Arg-Phe-Ser-Arg) mit schmerzstillender Wirkung, was noch untertrieben ist, denn Versuche an Ratten zeigten, dass Opiorphin eine 3 bis 6 mal hhere schmerzstillende Wirkung hat als Morphin [6]

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Figure 1 Evidence-based effects of key nutrients After understanding the pathological connection between nutrients and OA and discovering the significant role of the metabolism-inflammation-oxidative stress network in it, this study explores key nutrients that can prevent or treat OA through evidence-based medicine and reveals the mechanisms by which they exert preventive or therapeutic effects (Table 1)

ATF4 was found upregulated under cystine-limiting conditions, consistent with previous findings [16] (Fig