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Discussion The carcinogenic potency of the tobacco-specific nitrosamines NNN and NNK is well established, and the existing evidence indicates that these carcinogens can be nearly eliminated from tobacco products.13 14 A meaningful effort from the tobacco industry to make the necessary changes in their manufacturing approaches and dramatically reduce TSNA levels in cigarette filler, thus reducing smoke deliveries of these carcinogens,15 was anticipated to take place about a decade ago

July 3, 2007