glutathione reduced interaction with palladium Glutathione-Mediated Conjugation of Anticancer Drugs Palladium nanoparticles in lung cancer:

In the MPP + -induced PD model, Sirts were found to be degraded primarily through autophagy rather than the proteasome ( 2 O 2 or its decomposed products, oxidizes Sirts, which co-localise with autophagosomal structures and are degraded via autophagy

Zou J, Tan W, Liu K, Chen B, Duan T, Xu H

These cytokines induce matrix metalloproteinase (MMP) and the receptor activator of the nuclear factor-kB (RANK) ligand in the fibroblast which activates osteoclasts for bone destruction

Preclinical studies in rodent models have shown that LAN exposure, increases oxidative DNA damage, disrupts estrogen signaling and accelerates mammary tumor growth 22