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Cisplatin detoxification by GSH generally occurs by a reaction catalyzed by GST, in which GSH binds covalently to cisplatin and the formed GSH conjugates can be exported from the cells, preventing the drug from reaching its most important molecular target, DNA

Claudin-2 increases Na + and water flux across the pore pathway but larger molecules are unable to traverse claudin-2 channels

After a BUT pen with a certain concentration is correctly identified two times in a row the examiner continues with the triplet of pens, which includes the pen with the immediately lower BUT concentration

Cell Signaling Technology, Inc.), acyl-CoA synthase long-chain family member 4 (ACSL4