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Similar to the response evoked by microglia, astrocytes activated by A produced various pro-inflammatory compounds such as IL-1, IL-6, IL-18, TNF-, prostaglandins and ROS [241, 242]

36 1 H NMR (600 MHz, CDCl 3 ): 7.72 (s, 1H), 7.33 (s, 1H), 6.90 (t, J = 7.8 Hz, 1H), 6.83 (dd, J = 8.2, 0.7 Hz, 1H), 6.38 (dd, J = 7.5, 0.7 Hz, 1H), 5.625.53 (m, 1H), 5.24 (broad s, 1H), 5.034.92 (m, 2H), 3.75 (s, 3H), 3.69 (s, 3H), 3.313.25 (m, 1H), 3.23 (ddq, J = 15.2, 8.4, 2.6 Hz, 1H), 3.113.00 (m, 3H), 2.98 (ddt, J = 15.5, 4.3, 1.7 Hz, 1H), 2.76 (td, J = 11.7, 3.8 Hz, 1H), 2.60 (td, J = 11.3, 4.4 Hz, 1H), 2.342.25 (m, 1H), 2.152.04 (m, 1H), 1.94 (d, J = 12.4 Hz, 1H)

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