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Although GSH conjugation predominates at therapeutic APAP doses, GST-mediated detoxification becomes increasingly important as hepatic GSH levels decline during overdose (Coles et al

Joint replacement surgery has been a routine treatment for end-stage OA, but the timing of surgery is crucial because joint replacements will not survive forever [4]

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In one clinical trial, efficacy was equivalent to topical clindamycin at 16 weeks