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A typical research cycle runs 12 to 26 weeks of continuous daily dosing, followed by a washout period of at least 8 weeks

This action stabilizes Nrf2, allowing it to accumulate in the nucleus and bind to the Antioxidant Response Element (ARE) located in the enhancers of its target genes

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The project described was also supported by the National Center for Advancing Translational Sciences, National Institutes of Health, Award Number UL1TR002544